Microbial exposure regulates the development of anti-blood group antibodies. doi:10.4314/gmj.v49i1.11Īrthur CM, Sullivan HC, Gerner-Smidt C, et al. Rhesus negative woman transfused with rhesus positive blood: subsequent normal pregnancy without anti D production. Maya ET, Buntugu KA, Pobee F, Srofenyoh EK. History and current standard of postnatal management in hemolytic disease of the fetus and newborn. The Rh factor: how it can affect your pregnancy.ĭe Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E. doi:10.4103/jfmpc.jfmpc_252_17Īmerican College of Obstetricians and Gynecologists. Base Hospital, Srinagar, Uttarakhand, India. A retrospective study: ABO and Rh phenotype blood group distribution among blood donors in H.N.B. Kumar S, Modak PK, Ali SH, Barpanda SK, Gusain VS, Roy R. What is the Rh factor? Why is it important?Īmerican Red Cross. Any duplication or distribution of the information contained herein is strictly prohibited.American Red Cross. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. Links to other sites are provided for information only – they do not constitute endorsements of those other sites. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This site complies with the HONcode standard for trustworthy health information: verify here. Learn more about A.D.A.M.'s editorial policy editorial process and privacy policy. is among the first to achieve this important distinction for online health information and services. follows rigorous standards of quality and accountability. is accredited by URAC, for Health Content Provider (URAC's accreditation program is an independent audit to verify that A.D.A.M. This is because special immune globulins called RhoGAM are routinely used.Ī.D.A.M., Inc. This problem has become less common in places that provide good prenatal care. Rh incompatibility develops only when the mother is Rh-negative and the infant is Rh-positive. All children she has later who are also Rh-positive may be affected. This is because it takes time for the mother to develop antibodies. The level of bilirubin in the infant's blood may range from mild to dangerously high.įirstborn infants are often not affected unless the mother had past miscarriages or abortions. This causes an infant to become yellow (jaundiced). When red blood cells are broken down, they make bilirubin. They destroy the baby's circulating red blood cells. These antibodies may cross back through the placenta into the developing baby. The mother's body makes antibodies against the fetal blood cells. If the mother is Rh-negative, her immune system treats Rh-positive fetal cells as if they were a foreign substance. During pregnancy, red blood cells from the unborn baby can cross into the mother's blood through the placenta.
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